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The Effect of Cognitive Impairment on the Prognosis of Major Depressive Disorder.
- Source :
-
Journal of Nervous & Mental Disease . Sep2020, Vol. 208 Issue 9, p683-688. 6p. - Publication Year :
- 2020
-
Abstract
- The study recruited 168 patients diagnosed with major depressive disorder (MDD). The nine-item Patient Health Questionnaire (PHQ-9) and Perceived Deficits Questionnaire for Depression (PDQ-D) were lower and the Digit Symbol Substitution Test (DSST) was higher in the community volunteers than those in MDD patients. Depression-related scores (17-item Hamilton Depression Rating Scale [HAMD-17], Clinical Global Impressions-Severity of Illness Scale [CGI-S], and PHQ-9), functioning-related scores (Sheehan Disability Scale [SDS]), and Work Efficiency and Activity Damage-Specific Health Problems questionnaire work productivity loss were decreased, and the quality of life-related scores (European Quality of life-5 Dimensions [EQ-5D] utility score) were increased in the MDD patients. PDQ-D was decreased and DSST was increased with the increase of follow-up time. Linear regression indicated that cognitive symptoms (PDQ-D and DSST) improved more slowly than depressive symptoms (PHQ-9). At baseline, PDQ-D was related with functioning (SDS and work productivity loss). PDQ-D and DSST were related with EQ-5D utility score. In addition, at month 6, PDQ-D was related with functioning (SDS and work productivity loss) and EQ-5D utility score. Cognitive impairment might be a risk for MDD and MDD-related changes in the functioning and quality of life. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00223018
- Volume :
- 208
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Nervous & Mental Disease
- Publication Type :
- Academic Journal
- Accession number :
- 146817366
- Full Text :
- https://doi.org/10.1097/NMD.0000000000001180