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Combination Treatment with Human Adipose Tissue Stem Cellderived Exosomes and Fractional CO2 Laser for Acne Scars: A 12-week Prospective, Double-blind, Randomized, Split-face Study.
- Source :
-
Acta Dermato-Venereologica . Nov2020, Vol. 100 Issue 11, p1-8. 8p. - Publication Year :
- 2020
-
Abstract
- A variety of applications of human adipose tissue stem cell-derived exosomes have been suggested as novel cell-free therapeutic strategies in the regenerative and aesthetic medical fields. This study evaluated the clinical efficacy and safety of adipose tissue stem cell- derived exosomes as an adjuvant therapy after application of fractional CO2 laser for acne scars. A 12-week prospective, double-blind, randomized, split-face trial was performed. A total of 25 patients received three consecutive treatment sessions of fractional CO2 laser to the whole face, with a follow-up evaluation. Postlaser treatment regimens were applied; for each patient, one side of the face was treated with adipose tissue stem cell-derived exosomes gel and the other side was treated with control gel. Adipose tissue stem cell-derived exosomes-treated sides had achieved a significantly greater improvement than the control sides at the final follow-up visit (percentage reduction in échelle d'évaluation clinique des cicatrices d'acné scores: 32.5 vs 19.9%, p < 0.01). Treatment-related erythema was milder, and post-treatment downtime was shorter on the human adipose tissue stem cell-derived exosomes-treated side. In conclusion, the combined use of this novel material with resurfacing devices would provide synergistic effects on both the efficacy and safety of atrophic acne scar treatments. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADIPOSE tissues
*CARBON dioxide
*EXOSOMES
*SCARS
*CHEMICAL peel
*ACNE
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 100
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 146941359
- Full Text :
- https://doi.org/10.2340/00015555-3666