3D nanofibrous bioactive glass scaffolds produced by one-step spinning process.

In this work nanofibrous 3D scaffolds of bioactive glasses (58S, 60%SiO 2 –36%CaO–4%P 2 O 5 in mol and 63S, 65%SiO 2 –31%CaO–4%P 2 O 5 in mol) were produced by a one-step solution blow spinning (SBS) process. A green synthesis route was used with water as solvent and PVA (polyvinyl alcohol), 8 wt%, as a spinning agent. The physical properties of the scaffolds were studied, and their bioactivity assessed using simulated body fluid (SBF) and cell viability evaluated with MC3T3-E1 cells. After immersion in SBF, hydroxyapatite formed on the surface of the fibers within 12 h in both compositions. Pre-osteoblastic cells MC3T3-E1 were seeded on nanofiber surfaces and the bioactive glass scaffolds displayed enhanced cell number, protein synthesis and differentiation levels of alkaline phosphatase activity consistent with cytocompatibility. Such novel biomaterials have high potential to be used as scaffolds in tissue engineering for bone regeneration. • A novel route to produce 3D scaffolds by one step spinning process. • Bioactive glasses scaffolds with nanofibrous structure. • Nanofibrous scaffolds with high potential for use in bone regeneration. [ABSTRACT FROM AUTHOR]