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A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19.
- Source :
-
International Journal of Infectious Diseases . Nov2020, Vol. 100, p34-41. 8p. - Publication Year :
- 2020
-
Abstract
- • The incidence of VTE among hospitalised COVID-19 patients was high, particular among patients in ICU. • Anticoagulation was not associated with an increased risk of mortality in hospitalised COVID-19 patients. • Clinical trials are urgently needed to evaluate the roles of prophylactic and therapeutic anticoagulation in COVID-19. The incidence of venous thromboembolic events (VTE) in patients with COVID-19 is generally high but varies markedly. However, the relationship between anticoagulation and mortality in patients with COVID-19 is still unclear. We performed a systematic review and meta-analysis to determine the incidence of VTE and evaluate the role of anticoagulation in patients with COVID-19. Random effects models were used to determine overall pooled estimates and 95% confidence intervals (CIs). After a database search, 25 observational studies (20 on VTE incidence and 5 on the relationship between anticoagulation and mortality) were included. The pooled incidence rates of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in hospitalised COVID-19 patients were 21% (95% CI 15–27%), 15% (95% CI 10–20%), and 27% (95% CI 19–36%), respectively. A meta-analysis of five studies found that anticoagulation was not associated with an increased risk of mortality in hospitalised COVID-19 patients (RR = 0.86, 95% CI, 0.69–1.09, P = 0.218; I2 = 47.4%). In conclusion, the incidence of VTE among hospitalised COVID-19 patients was high. Clinical trials are urgently needed to evaluate the roles of prophylactic and therapeutic anticoagulation in COVID-19. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COVID-19
*ANTICOAGULANTS
*VENOUS thrombosis
*RANDOM effects model
Subjects
Details
- Language :
- English
- ISSN :
- 12019712
- Volume :
- 100
- Database :
- Academic Search Index
- Journal :
- International Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 147018996
- Full Text :
- https://doi.org/10.1016/j.ijid.2020.08.023