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Visualizing antithrombin-binding 3-O-sulfated heparan sulfate motifs on cell surfaces.
- Source :
-
Chemical Communications . 11/28/2020, Vol. 56 Issue 92, p14423-14426. 4p. - Publication Year :
- 2020
-
Abstract
- To map the cellular topography of the rare 3-O-sulfated structural motif of heparan sulfate (HS), we constructed quantum dot-based probes for antithrombin and FGF2, which reveal widely different distribution of the targeted HS motifs. The technology helps show that old and young aortic endothelia display widely different levels of the antithrombin-binding 3-O-sulfated HS motif. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPARAN sulfate
*CELL membranes
*TOPOGRAPHY
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 56
- Issue :
- 92
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 147158462
- Full Text :
- https://doi.org/10.1039/d0cc05893a