Back to Search
Start Over
Enantioselective Silylation of Aliphatic C−H Bonds for the Synthesis of Silicon‐Stereogenic Dihydrobenzosiloles.
- Source :
-
Angewandte Chemie International Edition . 12/1/2020, Vol. 59 Issue 49, p22217-22222. 6p. - Publication Year :
- 2020
-
Abstract
- A rhodium(I)‐catalyzed enantioselective silylation of aliphatic C−H bonds for the synthesis of silicon‐stereogenic dihydrobenzosiloles is demonstrated. This reaction involves a highly enantioselective intramolecular C(sp3)−H silylation of dihydrosilanes, followed by a stereospecific intermolecular alkene hydrosilylation leading to the asymmetrically tetrasubstituted silanes. A wide range of dihydrosilanes and alkenes displaying various functional groups are compatible with this process, giving access to a variety of highly functionalized silicon‐stereogenic dihydrobenzosiloles in good to excellent yields and enantioselectivities. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 49
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 147175441
- Full Text :
- https://doi.org/10.1002/anie.202009912