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Highly Regio‐, Diastereo‐, and Enantioselective Assembly of Azepino[2,3‐b]indoles viaPalladium‐Catalyzed [4 + 3] Cycloaddition†.
- Source :
-
Chinese Journal of Chemistry . Dec2020, Vol. 38 Issue 12, p1571-1574. 4p. - Publication Year :
- 2020
-
Abstract
- Summary of main observation and conclusion: A palladium‐catalyzed asymmetric [4 + 3] cycloaddition of trimethylenemethanes and indoline‐derived aza‐dienes has been developed. The potential [3 + 2] side pathway was completely suppressed in the process. This protocol provides an efficient access to azepino[2,3‐b]indoles bearing two vicinal stereocenters in generally excellent diastereo‐ and enantioselectivities (up to > 20 : 1 dr, 99% ee). [ABSTRACT FROM AUTHOR]
- Subjects :
- *RING formation (Chemistry)
*BEARINGS (Machinery)
*INDOLINE
*PALLADIUM
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 1001604X
- Volume :
- 38
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Chinese Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 147196312
- Full Text :
- https://doi.org/10.1002/cjoc.202000264