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Proteinase-activated receptor 2 promotes 3T3-L1 preadipocyte differentiation through activation of the PI3K/AKT signalling pathway and MAT2A gene expression.
- Source :
-
Archives of Physiology & Biochemistry . Dec2020, Vol. 126 Issue 5, p468-475. 8p. - Publication Year :
- 2020
-
Abstract
- The present study aimed to investigate the function and mechanisms of PAR2 in preadipocyte differentiation. This study found that the expression level of PAR2 was increased during 3T3-L1 mouse preadipocyte differentiation towards adipocytes. In addition, PAR2 overexpression significantly stimulated the expression of adipogenic proteins including ACC1, PPARĪ³, and SREBF1. Moreover, PAR2 overexpression increased the content of triglyceride (TG) in 3T3-L1 preadipocytes. Knockdown of PAR2 suppressed 3T3-L1 preadipocyte differentiation and adipogenesis. Mechanistically, PAR2 promoted 3T3-L1 preadipocyte differentiation and TG production through activation of the PI3K/AKT signalling pathway and MAT2A gene expression. The research sheds light on the adipogenic effects of PAR2 and its underlying mechanisms. Thus, PAR2 may have therapeutic significance for obesity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENE expression
*PROTEIN expression
Subjects
Details
- Language :
- English
- ISSN :
- 13813455
- Volume :
- 126
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Archives of Physiology & Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 147224556
- Full Text :
- https://doi.org/10.1080/13813455.2020.1817094