P.267 Association of chronotype and variation in the CLOCK gene in a large general European population sample.

B Introduction: b Mental health disorders have a huge impact on the well-being of the population, with affective disorders showing the highest prevalence and depression predicted to become the illness associated with the highest disease burden in the near future. B Aim: b The aim of the present study is to reveal associations between variation of the CLOCK gene, circadian phenotypes ascertained by the Morningness-Eveningness Questionnaire and lifetime depression in a large European general population sample. B Conclusion: b Investigating the genetic background of chronotype and its links to mood disorders contributes to elucidating biological pathways behind MDD and BD as well as alleviates a more precise estimation of the risk of developing depression. [Extracted from the article]