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Crocin suppressed cold allodynia and anxiety through α2- adrenoceptors in the anterior cingulate cortex following chronic constriction injury of sciatic nerve in rats.
- Source :
-
Journal of Research in Pharmacy . 2020, Vol. 24 Issue 6, p833-841. 9p. - Publication Year :
- 2020
-
Abstract
- It is believed that α-adrenoceptors have critical contribution in the process of pain information. Anterior cingulate of cortex (ACC) is a key area of brain associated with pain perception. Pharmacological studies demonstrated that crocin, as a potent antioxidant, has analgesic effects. The underlying analgesic mechanism of the crocin is far from clear. Therefore, the present study was design to examine the interaction of anti-nociceptive effects of crocin with α1- and α2-adrenoceptors of ACC in chronic constriction injury (CCI) model of neuropathic pain. Intra-ACC injection of crocin significantly decreased cold allodynia (using acetone test) and anxiety (using elevated plus maze test) in neuropathic rats from 2 days to 6 days' post-surgery. Co-injection of crocin and prazosin (α1-adrenoceptors antagonist, 30 μg/5μl) had no effect on the allodynia. However, co-injection of crocin and yohimbine (α2-adrenoceptors antagonist, 30 μg/5μl) significantly increased the allodynia on days 4 and 6 post-surgery as compared with CCI+crocin rats. Moreover, our data identified that neuropathy decreased open arm entries and locomotor activity. Additionally, crocin increased entries to open arms; but this increase was not significant as compared to CCI group. There was no significant difference between CCI+Crocin and CCI+crocin+prazosin groups. However, co-injection of crocin and yohimbine significantly decreased entries to open arms as compared with CCI+crocin group. Furthermore, co-injection of crocin with prazosin or yohimbine did not cause significant changes in locomotor activity. The present study suggested that the anti-nociceptive and anxiolytic effects of crocin appear to be mediated through α2-, and not α1-adrenoceptors in the ACC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 26306344
- Volume :
- 24
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Research in Pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 147289595
- Full Text :
- https://doi.org/10.35333/jrp.2020.242