Back to Search Start Over

Association between lipid fractions and age of first myocardial infarction.

Authors :
Bødtker, Henrik
Gunnersen, Stine
Adelborg, Kasper
Kulenovic, Imra
Kanstrup, Helle
Falk, Erling
Bruun, Jens Meldgaard
Mortensen, Martin Bødtker
Source :
Scandinavian Cardiovascular Journal. Dec2020, Vol. 54 Issue 6, p346-351. 6p.
Publication Year :
2020

Abstract

Dyslipidemia is a major cause of early coronary heart disease (CHD). Low-density-lipoprotein cholesterol (LDL-C), remnant cholesterol (remnant-C) and high-density lipoprotein cholesterol (HDL-C) have all been shown to be associated with risk of CHD. We aimed to compare the association of these lipid fractions with age at first myocardial infarction(MI). Design. Multicenter study of consecutive patients hospitalized with a first MI. Linear regression models were used to assess the independent association of LDL-C, remnant-C and HDL-C with age at first MI. Results. The study included 1744 patients. In univariate analyses, LDL-C, remnant-C, and HDL-C were all significantly associated with age at first MI. However, in multivariate analyses only LDL-C [−2.5 years (95%CI: −3.1 to −1.8) per 1 SD increase] and to a lesser extent remnant-C [−0.9 years (95% CI: −1.5 to −0.3)] continued to be associated with age of MI, while HDL-C [0.5 years (95%CI: −0.2 to 1.2)] was not. Conclusions. LDL-C is the lipid fraction strongest associated with younger age of presentation of first MI. These results support the importance of controlling and treating LDL-C in prevention of premature MI. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14017431
Volume :
54
Issue :
6
Database :
Academic Search Index
Journal :
Scandinavian Cardiovascular Journal
Publication Type :
Academic Journal
Accession number :
147339098
Full Text :
https://doi.org/10.1080/14017431.2020.1770850