Back to Search
Start Over
Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study.
- Source :
-
American Journal of Epidemiology . Dec2020, Vol. 189 Issue 12, p1538-1546. 9p. - Publication Year :
- 2020
-
Abstract
- Uterine leiomyomata (UL) are associated with severe reproductive morbidity and are the primary indication for hysterectomy in the United States. A recent prospective cohort study of Black women reported positive associations between intakes of marine-sourced ω-3 fatty acids and UL risk. We examined whether intakes of dietary fat were associated with UL incidence in a 5-year prospective study of premenopausal Black women living in Detroit who underwent serial ultrasound. At baseline (2010–2012) and 20, 40, and 60 months of follow-up, participants underwent transvaginal ultrasound. Among 1,171 UL-free women at baseline, incident UL were detected in 277 women. Cox regression was used to estimate hazard ratios and 95% confidence intervals for the association of dietary fat and UL incidence. Intakes of total fat and saturated, monounsaturated, polyunsaturated, and trans -fat were not appreciably associated with UL incidence. Intake of the marine ω-3 polyunsaturated fatty acid, docosahexaenoic acid, was associated with 49% higher UL incidence (quartile 4 vs. 1: hazard ratio = 1.49, 95% confidence interval: 1.04, 2.14; P for trend = 0.01). Intakes of total marine ω-3 polyunsaturated fatty acids were similarly associated with elevated UL incidence (hazard ratio = 1.35, 95% confidence interval: 0.94, 1.93; P for trend = 0.03). It remains unclear whether the fatty acids or persistent environmental pollutants drive the association. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLACK people
*CONFIDENCE intervals
*ENDOSCOPIC ultrasonography
*FAT content of food
*INGESTION
*LONGITUDINAL method
*OMEGA-3 fatty acids
*UNSATURATED fatty acids
*UTERINE fibroids
*UTERINE tumors
*WOMEN'S health
*PERIMENOPAUSE
*DOCOSAHEXAENOIC acid
*DISEASE incidence
*PROPORTIONAL hazards models
*DESCRIPTIVE statistics
*EARLY detection of cancer
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 00029262
- Volume :
- 189
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 147366680
- Full Text :
- https://doi.org/10.1093/aje/kwaa097