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Highly selective recognition of intramolecular parallel G-quadruplex using a chiral supramolecular probe.
- Source :
-
Dyes & Pigments . Feb2021:Part A, Vol. 185, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Owing to their chiral and self-assembly features, chiral supramolecules exhibit superior recognition and catalytic abilities. Here, we construct a chiral H-aggregates based on a cyanine dye, 3,3′-di(3-sulfopropyl)-4,5,4′5′-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MeCy), by spontaneous symmetry breaking in the presence of NaNO 3. The chiral H-aggregates could specially recognize parallel DNA G-quadruplexes among other DNA types, probably by a three-step process, which comprises the amplified chiral induction, the disassembly of chiral H-aggregates and the binding of the MeCy monomer. The MeCy monomer binding to DNA parallel G-quadruplex led to a lighting-up fluorescence intensity obviously. Chiral supramolecules targeted to DNA G-quadruplex was proposed, and its transformation process was revealed, and thus potentially provided an excellent probe for DNA parallel G-quadruplexes. To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered. Image 1 • A chiral supramolecular probe targeting to DNA G-quadurplex was proposed. • The chiral H-aggregates could specially recognize parallel DNA G-quadruplexes among other DNA types. • Chiral H-aggregates could disassociate into its monomer by a lighting-up protocol interacting with parallel G-quadruplexes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ASYMMETRIC synthesis
*DNA probes
*SYMMETRY breaking
*CYANINES
*MONOMERS
Subjects
Details
- Language :
- English
- ISSN :
- 01437208
- Volume :
- 185
- Database :
- Academic Search Index
- Journal :
- Dyes & Pigments
- Publication Type :
- Academic Journal
- Accession number :
- 147484292
- Full Text :
- https://doi.org/10.1016/j.dyepig.2020.108882