Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients.

The article focuses on a study which analyzed patients having de novo germline mutations in histone 3 family 3A or H3F3B with progressive neurologic dysfunction and congenital anomalies without malignancies. Disruptions in interactions with DNA, other histones and histone chaperone proteins were exhibited by molecular modeling of all variants. Data shows that the germline mutations mechanism are unique from cancer-related somatic histone mutations but may merge on control of cell proliferation.