HPVomics: An integrated resource for the human papillomavirus epitome and therapeutics.

Human papillomaviruses (HPVs) belongs to the Papillomaviridae family, which is divided into high-risk (HR), and low-risk (LR) HPVs based on their disease-causing competence. HR-HPVs 16 and 18 are known to cause distinct carcinomas like cervical and head and neck, whereas LR-HPVs are commonly associated with the genital warts. We have developed an integrative platform; HPVomics dedicated to the potential therapeutic regimens targeting all HPV genes including oncoproteins E6, E7 and E5. We primarily focused on eighteen HR-HPVs and eleven LR-HPVs. It mainly deals with therapeutically imperative elements, i.e., vaccine epitopes, siRNAs, sgRNAs, and anti-viral peptides. Simultaneously, it also comprises of genome browser, whole-genome sequences and annotation of HPVs with searching and filtering capabilities. Moreover, we have also developed an integrated support vector machine (SVM) based computational algorithm " HPVepi " for the prediction of HPV epitome. We hope that HPVomics (http://bioinfo.imtech.res.in/manojk/hpvomics/) will assist the scientific community engaged in HPV research. • Human papillomaviruses (HPVs) play a cardinal role in diverse carcinomas. • HPVomics is an integrated resource dedicated to the HPV therapeutics and epitome. • Deliver therapeutically vital components i.e., vaccine epitopes, siRNAs, sgRNAs, etc. • HPVepi: HPV epitope prediction algorithm developed. • It is freely available at https://bioinfo.imtech.res.in/manojk/hpvomics/ [ABSTRACT FROM AUTHOR]