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DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension.
- Source :
-
Science Advances . 12/9/2020, Vol. 6 Issue 50, p1-13. 13p. - Publication Year :
- 2020
-
Abstract
- The article discusses the critical role of DNA methylation in the vascular pathology of pulmonary hypertension (PH). Topics include a study which showed that global DNA methylation in the lungs of PH rat models following monocrotaline administration or hypobaric hypoxia exposure, the up-regulation of DNA methyl-transferase 3B (DNMT3B), and the migration of pulmonary artery smooth muscle cells (PASMC).
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 6
- Issue :
- 50
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 147634929
- Full Text :
- https://doi.org/10.1126/sciadv.aba2470