间充质干细胞治疗椎间盘退行性疾病：基于 Web of Science 数据库的 文献计量及可视化分析.

BACKGROUND: Mesenchymal stem cells have the characteristics of self-renewal and multi-directional differentiation, and have great potential and application prospects in the treatment of intervertebral disc diseases. OBJECTIVE: To analyze the literature of mesenchymal stem cells in the treatment of intervertebral disc degenerative diseases using bibliometric analysis, and to understand the research trends and hotspots in this field, and to provide basis and suggestions for its follow-up development. METHODS: With the theme of mesenchymal stem cell therapy for intervertebral disc degeneration, we searched the relevant literature included in the Web of Science database from 2000 to 2019, analyzed the annual number of paper published, and scientific research funding. Citespace5.5.R2 software was used to analyze the cooperation relationship of authors, countries and research institutions, the co-citation of journals or literatures. Finally, cluster analysis, burst analysis and time zone graph analysis were performed on keywords. RESULTS AND CONCLUSION: (1) A total of 648 papers were included, with journal articles as the main type of literature. (2) Most of the funding were sponsored by China and USA (more than 50%). (3) A total of 206 authors were included, out of whom 70 authors published more than 3 papers, and the principal researchers were Daisuke Sakai (Japan) focusing on mesenchymal stem cells transplantation for intervertebral disc degeneration, Judith A Hoyland (Great Britain) focusing on regulation of myeloid cell phenotype by mesenchymal stem cells, and Makarand V Risbud (US) focusing on induction of mesenchymal stem cell differentiation. (4) 125 countries and institutions were included: China and USA were the two main countries. (5) 154 journals were included, as SPINE was the journal with the most published articles. (6) The keyword analysis showed that the research in this field can be divided into three phases: phase 1 from 2005 to 2012, mainly investigating gene expression differences, chondrogenic differentiation of mesenchymal stem cells, and extracellular matrix changes in the intervertebral disc; phase 2 from 2012 to 2017, mainly investigating mesenchymal stem cell injection therapy and changes in the microenvironment of the intervertebral disc; phase 3 from 2017 to 2019, the main study is cell therapy and disc regeneration promoted by mesenchymal stem cells. (7) The probably research direction was to extract mesenchymal stem cells and induce their differentiation to nucleus pulposus, paracrine secretion of mesenchymal stem cells on the function of disc cells and mesenchymal stem cells combined with tissue engineering technology to promote intervertebral disc regeneration. [ABSTRACT FROM AUTHOR]