诱导多能干细胞在骨外科组织工程中的应用与作用.

BACKGROUND: Induced pluripotent stem cells have many advantages such as differentiation totipotency, wide source, easy access and no ethical constraints, so they rapidly become promising seed cells in the field of tissue engineering. OBJECTIVE: To review the progress of induced pluripotent stem cells in bone surgery tissue engineering. METHODS: The electronic database PubMed was searched by the first author. The key words were “iPSCs, osteanagenesis, tendon, spinal cord, spinal cord, tissue engineering, regenarative medicine”. The literature published from 2000 to 2020 was searched. A total of 50 articles were selected as references for review, screening the documents with strong relevance and excluding those with little content. RESULTS AND CONCLUSION: Compared with mesenchymal stem cells and embryonic stem cells, induced pluripotent stem cells have many advantages, such as wide source, easy access, no ethical constraints and controllable gene instability, reducing immune rejection. Induced pluripotent stem cells technology in bone surgery tissue engineering research showed satisfactory results. Key words: stem cells; induced pluripotent stem cells; tendon; bone; cartilage; spinal cord; tissue engineering; review [ABSTRACT FROM AUTHOR]