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N-acetylglucosamine drives myelination by triggering oligodendrocyte precursor cell differentiation.
- Source :
-
Journal of Biological Chemistry . 12/18/2020, Vol. 295 Issue 51, p17413-17424. 12p. - Publication Year :
- 2020
-
Abstract
- Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling, and endocytosis. GlcNAc is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting platelet-derived growth factor receptor-a cell endocytosis. Supplying oral GlcNAc to lactating mice drives primarymyelination in newborn pups via secretion in breast milk, whereas genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone)-induced demyelination, oral GlcNAc prevents neuroaxonal damage by driving myelin repair. In MS patients, endogenous serumGlcNAc levels inversely correlated with imagingmeasures of demyelination and microstructural damage. Our data identify N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggest that oral GlcNAcmay be neuroprotective in demyelinating diseases likeMS. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219258
- Volume :
- 295
- Issue :
- 51
- Database :
- Academic Search Index
- Journal :
- Journal of Biological Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 147707648
- Full Text :
- https://doi.org/10.1074/jbc.RA120.015595