Formulation and Evaluation of Oro-dispersible Tablets of Ondansetron Hydrochloride by Direct Compression Method.

The main aim of this research paper is to formulate and evaluate Orodispersible tablets of OndasetronHCl by direct compression method. The oral route of drug administration is that the most vital method for administering drugs for systemic effects. For rapid dissolution of dosage, water must rapidly penetrate into the tablet matrix to cause quick disintegration and instantaneous dissolution may be a fundamental to formulate ODT. Oro-dispersible tablets of ondansetron hydrochloride are prepared by direct compression method. The formulation 75% of super disintegrate (i.e) Starch Glycolate and Cross Povidone, Ac Di Sol & Microcrystalline Cellulose pH102 has shown best release with 99.46% at the top of 30 minutes the bubbling mixture further assists in taste masking of Ondansetron hydrochloride. Consistent with IR studies there's no incompatibility shown. The formulation found stable at 40°C±2°C and 75%RH±5%RH. [ABSTRACT FROM AUTHOR]