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Association between serum albumin and peripheral arterial disease in hypertensive patients.
- Source :
-
Journal of Clinical Hypertension . Dec2020, Vol. 22 Issue 12, p2250-2257. 8p. - Publication Year :
- 2020
-
Abstract
- The authors aimed to evaluate the relationship of serum albumin with peripheral arterial disease (PAD) and investigate any possible effect modifiers in hypertensive patients. In the cross-sectional study, a total of 10,900 Chinese hypertensive patients aged ≥18 years were enrolled. The outcome was PAD, defined as an ankle-brachial index (ABI) <0.90 in either leg. The overall mean (SD) serum albumin was 46.8 (4.2) g/L. There were significant inverse associations of serum albumin with PAD (per SD increment; OR: 0.83; 95% CI: 0.72, 0.94). Compared with the lowest tertile (<45.1 g/L), the multivariate-adjusted ORs (95% CI) for participants in the middle tertile (45.1-48.2 g/L) and highest tertile (≥48.2 g/L) of serum albumin were 0.89 (95% CI: 0.67, 1.16) and 0.65 (95% CI: 0.47, 0.90), respectively. Conversely, lower albumin (<48.2 g/L) concentrations were associated with increased odds of PAD (OR: 1.45; 95% CI: 1.08-1.96) compared with higher concentrations. Furthermore, the albumin-PAD association was significantly stronger in males (OR: 2.08; 95% CI: 1.31, 3.30) than in females (OR: 1.06; 95% CI: 0.70, 1.58; p interaction = .024). In conclusion, among Chinese hypertensive adults, lower serum albumin was associated with the prevalence of PAD only in males but not in females. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15246175
- Volume :
- 22
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Clinical Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 147714259
- Full Text :
- https://doi.org/10.1111/jch.14071