Carbohydrate‐induced weight gain models for diabetes research: Contribution of incretins and parasympathetic signal.

Carbohydrate includes both fibers and sugars. In Kir6.2-deficient (Kir6.2KO) mice, glucose-induced insulin secretion and response to incretins are severely impaired, whereas insulin secretion induced through the vagal nerve is maintained. The excessive secretion of insulin observed in ST-fed Kir6.2KO mice; that is, cephalic phase-mediated insulin secretion, plays a more important role in ST-fed mice than it does in NC-fed mice. [Extracted from the article]