A Mn(II)-coordination polymer: selective detection of Fe3+ ion and treatment activity on sepsis via reducing the inflammatory cytokines releasing.

In the current research, a new Mn(II)-based coordination polymer, {(NH2Me)2[Mn4(Hntb)4(4,4′-bpy)(OH)2] DMF} (1) have been formed by mixing the ligands of H3ntb (4,4′,4′′-nitrilotris-benzoic) and 4,4′-bpy (4,4′-bipyridine). According to the results of UV detection, complex 1 has strong blue luminescence, which means that it can be used as a fluorescent probe for specific detection of Fe3+ ion in water with a Ksv value of 3.2 × 104 M−1. Furthermore, the treatment activity of the compound on sepsis treatment was assessed and the protentional mechanism was revealed. Firstly, the inflammatory cytokines released into the plasma was measured with ELISA detection kit. Then, the survival rate of the infected animals was recorded after compound treatment. [ABSTRACT FROM AUTHOR]