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Cell-free Systems: Recent Advances and Future Outlook.

Authors :
Koo, Jamin
Yang, Jiho
Park, Hyunjun
Source :
Biotechnology & Bioprocess Engineering. 2020, Vol. 25 Issue 6, p955-961. 7p.
Publication Year :
2020

Abstract

Cell-free systems utilize a subset of cellular components without intact cell wall and/or membranes. The system was first invented for use in fermentation. Subsequent improvements enabled its application in protein synthesis, which is still the most common use of the system. Lately, attempts have been reported where metabolic engineering concepts and techniques were applied to cell-free systems and/or vice-versa. These attempts and advances led to exciting discoveries about biochemical reactions, as well as properties and/or structures of cellular components that make up complex biological systems. This review will first provide a basic overview and brief history of the cell-free system. Then, explanation on recent advances in the field will be provided, followed by notes on the innovative applications. Future outlook of the field will also be covered with the emphasis on how the emerging data science methods can be applied to improve the system and its applicability. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
12268372
Volume :
25
Issue :
6
Database :
Academic Search Index
Journal :
Biotechnology & Bioprocess Engineering
Publication Type :
Academic Journal
Accession number :
147968116
Full Text :
https://doi.org/10.1007/s12257-020-0013-x