Two transition metal coordination polymers: Magnetic investigation and treatment activity on children chronic myocarditis by regulating the hs-cTnT expression.

In the current study, by solvothermal reaction of Cu(NO 3) 2 ·3H 2 O or Co(NO 3) 2 ·6H 2 O with the H 4 Tdada ligand in a mixed solvent of H 2 O and DMA, two novel coordination polymers (CPs) were prepared and their chemical formulae are {[(CH 3) 2 NH 2 ] 2 [Co(Tdada)](H 2 O) 3 } n (1) and {[Cu 2 (Tdada)(H 2 O)(DMA)](DMA) 3 } n (2 , H 4 Tdada ​= ​5,5′-((thiophene-2,5-dicarbonyl) bis(azanediyl)) diisophthalic acid). The single crystal X-diffraction studies show that compound 1 shows a 3D 2-fold interpenetrated framework with a 4-connected dia topology and compound 2 shows a non-interpenetrated framework with a 4-connected lon topology. The magnetic investigations indicate that the two compounds possess antiferromagnetic coupling between neighboring metallic ions, and the Curie-Weiss constant is −7.5 ​K for 1 and -6.04 ​K for 2 , respectively. Their treatment activity on viral myocarditis was evaluated and the related mechanism was discussed at the same time. First of all, the Cell Counting Kit-8 was carried out to evaluate the toxicity of compounds 1 and 2. The Annexin V-FITC Apoptosis Detection Kit was conducted and the apoptosis of the virus infected cardiomyocytes was measured. In addition to this, the ELISA detection was used to measure the hs-cTnT in the cardiomyocytes after compound 1 or 2 treatment. Image 1 • Two novel coordination polymers were solvothermally prepared. • The magnetic investigations indicate their antiferromagnetic interactions. • The apoptosis of the virus infected cardiomyocytes was measured. [ABSTRACT FROM AUTHOR]