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Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2.
- Source :
-
International Immunopharmacology . Jan2021, Vol. 90, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SARS-CoV-2
*EGGS
*EGG yolk
*COVID-19
*MUTANT proteins
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 90
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 148075533
- Full Text :
- https://doi.org/10.1016/j.intimp.2020.107172