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Amygdala functional connectivity in major depression – disentangling markers of pathology, risk and resilience.
- Source :
-
Psychological Medicine . Dec2020, Vol. 50 Issue 6, p2740-2750. 11p. - Publication Year :
- 2020
-
Abstract
- Background: Limbic-cortical imbalance is an established model for the neurobiology of major depressive disorder (MDD), but imaging genetics studies have been contradicting regarding potential risk and resilience mechanisms. Here, we re-assessed previously reported limbic-cortical alterations between MDD relatives and controls in combination with a newly acquired sample of MDD patients and controls, to disentangle pathology, risk, and resilience. Methods: We analyzed functional magnetic resonance imaging data and negative affectivity (NA) of MDD patients (n = 48), unaffected first-degree relatives of MDD patients (n = 49) and controls (n = 109) who performed a faces matching task. Brain response and task-dependent amygdala functional connectivity (FC) were compared between groups and assessed for associations with NA. Results: Groups did not differ in task-related brain activation but activation in the superior frontal gyrus (SFG) was inversely correlated with NA in patients and controls. Pathology was associated with task-independent decreases of amygdala FC with regions of the default mode network (DMN) and decreased amygdala FC with the medial frontal gyrus during faces matching, potentially reflecting a task-independent DMN predominance and a limbic-cortical disintegration during faces processing in MDD. Risk was associated with task-independent decreases of amygdala-FC with fronto-parietal regions and reduced faces-associated amygdala-fusiform gyrus FC. Resilience corresponded to task-independent increases in amygdala FC with the perigenual anterior cingulate cortex (pgACC) and increased FC between amygdala, pgACC, and SFG during faces matching. Conclusion: Our results encourage a refinement of the limbic-cortical imbalance model of depression. The validity of proposed risk and resilience markers needs to be tested in prospective studies. Further limitations are discussed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMYGDALOID body physiology
*MENTAL depression genetics
*MENTAL depression risk factors
*AMYGDALOID body
*BIOMARKERS
*COMPARATIVE studies
*STATISTICAL correlation
*MENTAL depression
*FACE
*FRONTAL lobe
*MAGNETIC resonance imaging
*MATHEMATICAL models
*PSYCHOLOGY
*PSYCHOLOGICAL resilience
*RISK assessment
*PHENOTYPES
*TASK performance
*FAMILY history (Medicine)
*FUNCTIONAL connectivity
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 50
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 148113231
- Full Text :
- https://doi.org/10.1017/S0033291719002885