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Light‐Promoted Copper‐Catalyzed Enantioselective Alkylation of Azoles.
- Source :
-
Angewandte Chemie . 1/25/2021, Vol. 133 Issue 4, p2158-2162. 5p. - Publication Year :
- 2021
-
Abstract
- A catalytic asymmetric alkylation of azoles with secondary 1‐arylalkyl bromides through direct C−H functionalization is reported. Under blue‐light photoexcitation, a copper(I)/carbazole‐based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 133
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 148162231
- Full Text :
- https://doi.org/10.1002/ange.202009323