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1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer.

Authors :
Kilgour, Marisa K.
MacPherson, Sarah
Zacharias, Lauren G.
Ellis, Abigail E.
Sheldon, Ryan D.
Liu, Elaine Y.
Keyes, Sarah
Pauly, Brenna
Carleton, Gillian
Allard, Bertrand
Smazynski, Julian
Williams, Kelsey S.
Watson, Peter H.
Stagg, John
Nelson, Brad H.
DeBerardinis, Ralph J.
Jones, Russell G.
Hamilton, Phineas T.
Lum, Julian J.
Source :
Science Advances. 1/20/2021, Vol. 7 Issue 4, p1-14. 14p.
Publication Year :
2021

Abstract

The article offers information about the immune regulatory metabolites are key features of the tumor microenvironment. It mentions a study that profiled tumor and T cells from tumor and ascites of patients with high-grade serous carcinoma (HGSC) to uncover the metabolomes of these distinct TME compartments.

Subjects

Subjects :
*GLYCOLYSIS
*ASCITIC fluids
*OVARIAN cancer
*CYTOTOXIC T cells
*ORGANIC cation transporters

Details

Language :
English
ISSN :
23752548
Volume :
7
Issue :
4
Database :
Academic Search Index
Journal :
Science Advances
Publication Type :
Academic Journal
Accession number :
148295696
Full Text :
https://doi.org/10.1126/sciadv.abe1174
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