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Point‐of‐care semen analysis of patients with infertility via smartphone and colorimetric paper‐based diagnostic device.
- Source :
-
Bioengineering & Translational Medicine . Jan2021, Vol. 6 Issue 1, p1-11. 11p. - Publication Year :
- 2021
-
Abstract
- Male infertility affects millions of males worldwide and is rising in prevalence due to social and environmental conditions. However, men often feel too embarrassed to receive a semen analysis in the hospital due to social stigmas. To overcome this problem, we developed a 3‐(4,5‐Dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide test strip to distinguish semen samples with low total motile sperm concentration from those with normal motile sperm concentration. This is a point‐of‐care colorimetric semen analytical method with a one‐step, inexpensive, equipment‐free evaluation process, and adequate accuracy validated in a 42‐sample clinical trial. In this study, results were evaluated visually and with a smartphone application. Using visual observation methods, the area under the curve (AUC) was 0.71 (95% of confidence interval = 0.55–0.86; p = 0.021), sensitivity was 41%, specificity was 95%, positive predictive value was 90%, negative predictive value (NPV) was 59.4%, and accuracy was 67%. Using a smartphone recording and analytical system, AUC was 0.766 (95% of confidence interval = 0.612–0.92; p = 0.003), sensitivity was 96%, specificity was 65%, PPV was 75%, NPV was 92.9%, and accuracy was 80.9%. This work demonstrated a screening tool that could elevate semen analysis to the level of routine healthcare and provide for private, in‐home self‐assessment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23806761
- Volume :
- 6
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Bioengineering & Translational Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 148306877
- Full Text :
- https://doi.org/10.1002/btm2.10176