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Preventive Administration of Melatonin Attenuates Electrophysiological Consequences of Myocardial Ischemia.
- Source :
-
Bulletin of Experimental Biology & Medicine . 2020, Vol. 169 Issue 3, p328-331. 4p. - Publication Year :
- 2020
-
Abstract
- The effect of preventive administration of melatonin on the arrhythmogenic substrate in the myocardium was studied in the rabbit model of acute ischemia/reperfusion in vivo. The animals treated with melatonin 60 min before ischemia induction had shorter median activation time compared to the control group (p=0.039), less pronounced shortening of repolarization durations in the ischemic zone during coronary occlusion (p=0.008), and more complete recovery of repolarization during reperfusion (p=0.027). In the melatonin group, the dispersion of repolarization was less than in the control group during both ischemic period (p=0.043) and reperfusion (p=0.038). Thus, preventive administration of melatonin mitigated the arrhythmogenic substrate in the heart under conditions of ischemia/reperfusion. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00074888
- Volume :
- 169
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Bulletin of Experimental Biology & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 148389471
- Full Text :
- https://doi.org/10.1007/s10517-020-04881-y