Bone-targeting polymer vesicles for simultaneous imaging and effective malignant bone tumor treatment.

We present a bone-targeting polymer vesicle with excellent single photon emission computed tomography/computed tomography (SPECT/CT) imaging capability and high antitumor drug delivery efficiency as an integrated platform for the simultaneous diagnosing and treatment of malignant bone tumors. This polymer vesicle can be self-assembled from poly(ε -caprolactone) 67 - b -poly[(L -glutamic acid) 6 - stat -(L -glutamic acid-alendronic acid) 16 ] (PCL 67 - b -P[Glu 6 - stat -(Glu-ADA) 16 ]), directly in water without the aid of a cosolvent. SPECT/CT dynamically tracked the drug distribution in the bone tumor rabbit models, and the tumor size was significantly reduced from >2.0 cm3 to <0.6 cm3 over 11 days. The pathological analysis demonstrated obvious necrosis and apoptosis of the tumor cells. Overall, this bone-targeting polymer vesicle provides us with a new platform for the combination of real-time diagnosis and therapy of malignant bone tumors. Image 1 [ABSTRACT FROM AUTHOR]