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A high-throughput, ultrafast, and online three-phase electro-extraction method for analysis of trace level pharmaceuticals.
- Source :
-
Analytica Chimica Acta . Mar2021, Vol. 1149, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Sample preparation is often reported as the main bottleneck of analytical processes. To meet the requirements of both high-throughput and high sensitivity, improved sample-preparation methods capable of fast analyte preconcentration are urgently needed. To this end, a new three-phase electroextraction (EE) method is presented that allows for ultrafast electroextraction hyphenated to flow-injection analysis mass spectrometry (FIA-MS). Four model compounds, i.e., propranolol, amitriptyline, bupivacaine, and oxeladin, were used to optimize and evaluate the method. Within only 30 s extraction time, enrichment factors (EF) of 105–569 and extraction recoveries (ER) of 10.2%–55.7% were achieved for these analytes, with limits of detection (LODs) ranging from 0.36 to 3.21 ng mL−1, good linear response function (R2 > 0.99), low relative standard deviation (0.6%–17.8%) and acceptable accuracy (73–112%). Finally, the optimized three-phase EE method was successfully applied to human urine and plasma samples. Our three-phase electroextraction method is simple to construct and offers ultrafast, online extraction of trace amounts of analytes from biological samples, and therefore has great potential for high-throughput analysis. Image 1 • Ultrafast analyte extraction, down to 30 s. • High enrichment factors of up to 569-fold. • Direct hyphenation to MS. • Simple extraction setup. • Limit of detection as low as 360 pg/mL. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TRACE analysis
*MASS analysis (Spectrometry)
*ELECTROWINNING
*DETECTION limit
Subjects
Details
- Language :
- English
- ISSN :
- 00032670
- Volume :
- 1149
- Database :
- Academic Search Index
- Journal :
- Analytica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 148501533
- Full Text :
- https://doi.org/10.1016/j.aca.2021.338204