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Interleukin 35: An overview.
- Source :
-
Polish Annals of Medicine . 2020, Vol. 27 Issue 2, p225-229. 5p. - Publication Year :
- 2020
-
Abstract
- Introduction: Interleukin 35 (IL-35) has recently been characterized as a cytokine connected with the IL-12 group. The secretion of IL-35 was described in forkhead box protein 3 (Foxp3) + regulatory T cells (Tregs), peripheral γπ T cells, CD8+ T cells, placental trophoblasts, antigen-presenting cells (APCs) and regulatory B cells (Breg). Aim: The aim of this paper is to systematize current knowledge about IL-35 production and discuss its impact on the pathophysiology and outcome of various diseases. Material and methods: Literature review was conducted. Results and discussion: IL-35 plays a pivotal role in the immune dysregulation in the pathogenesis of cardiovascular diseases including atherosclerosis, psychiatric and neurologic disorders, cancer, allergic and autoimmune diseases and psoriasis, inducing the expression of Treg-related cytokines and inhibiting the expression of Th1- and Th17-related cytokines. Conclusions: Due to the numerous signaling pathways of IL-35, it may be described as an innovative biomarker in the prognosis and treatment of various diseases. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 12308013
- Volume :
- 27
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Polish Annals of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 148532767
- Full Text :
- https://doi.org/10.29089/2020.20.00130