Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes.

The article discusses escape of large macromolecular complexes from the endoplasmic reticulum (ER), such as a viral particle or cellular aggregate, induces mechanical stress initiated on the luminal side of the ER membrane. Topics include the action of RTN counters presumably by deploying curvature-inducing activity to provide membrane flexibility and stability to limit mechanical stress; and the cytosolic leaflet ER morphogenic protein reticulon (RTN) protects ER membrane integrity.