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Reticulon protects the integrity of the ER membrane during ER escape of large macromolecular protein complexes.
- Source :
-
Journal of Cell Biology . Feb2020, Vol. 219 Issue 2, p1-13. 13p. - Publication Year :
- 2020
-
Abstract
- The article discusses escape of large macromolecular complexes from the endoplasmic reticulum (ER), such as a viral particle or cellular aggregate, induces mechanical stress initiated on the luminal side of the ER membrane. Topics include the action of RTN counters presumably by deploying curvature-inducing activity to provide membrane flexibility and stability to limit mechanical stress; and the cytosolic leaflet ER morphogenic protein reticulon (RTN) protects ER membrane integrity.
- Subjects :
- *NUCLEOTIDE exchange factors
*SV40 (Virus)
*UNFOLDED protein response
Subjects
Details
- Language :
- English
- ISSN :
- 00219525
- Volume :
- 219
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 148572134
- Full Text :
- https://doi.org/10.1083/jcb.201908182