Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.

The article presents the discussion on determining the gene-regulatory networks driving human disease allowing the design of therapies targeting the core disease. Topics include In silico correlation of disease network dysregulation with pathways affected by molecules in surrogate cell types; and mapping the architecture of the dysregulated network in disease-relevant cells differentiating from patient-derived induced pluripotent stem cells (iPSCs).