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'Sugarcoating' 2-deoxyglucose: mechanisms that suppress its toxic effects.
- Source :
-
Current Genetics . Feb2021, Vol. 67 Issue 1, p107-114. 8p. - Publication Year :
- 2021
-
Abstract
- Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathways that play a role in 2-deoxyglucose sensitivity and discuss how the modifications to these pathways result in acquisition of 2-deoxyglucose resistance. Insights gained from genetic and proteomic studies in yeast provide new ideas for the design of combinatorial therapies for cancer treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01728083
- Volume :
- 67
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Current Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 148754232
- Full Text :
- https://doi.org/10.1007/s00294-020-01122-7