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Discovery of remogliflozin etabonate: A potent and highly selective SGLT2 inhibitor.
- Source :
-
Bioorganic & Medicinal Chemistry . Mar2021, Vol. 34, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- We optimized the structure of an active metabolite (1) of WAY-123783, which was obtained from mouse urine after oral administration, to improve selectivity for SGLT2 and oral bioavailability. O -glucoside derivative 24 (remogliflozin etabonate) was subsequently identified as a potent, highly selective, and orally available SGLT2 inhibitor. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SODIUM-glucose cotransporter 2 inhibitors
*IMIDAZOPYRIDINES
*TYPE 2 diabetes
Subjects
Details
- Language :
- English
- ISSN :
- 09680896
- Volume :
- 34
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 148806763
- Full Text :
- https://doi.org/10.1016/j.bmc.2021.116033