Liquid biopsy proteomics of uveal melanoma reveals biomarkers associated with metastatic risk.

1 Targeted proteomic signatures differentiate molecular classes of uveal melanoma: a The vitreous contains native vitreous proteins, systemic protein biomarkers, and tumor biomarkers that can be sampled through proteomic analysis. Our research has demonstrated that retinal proteins leak into the vitreous, and that proteomic analysis of vitreous biopsies can detect molecular changes in the adjacent retina, uncover biomarkers, and identify protein targets for adjuvant therapy [[6]]. Keywords: Proteomics; Vitreous; Liquid biopsy; Uveal melanoma; Cancer; Biomarker; SCFR; HGFR; STAT3 EN Proteomics Vitreous Liquid biopsy Uveal melanoma Cancer Biomarker SCFR HGFR STAT3 1 5 5 03/02/21 20210224 NES 210224 Supplementary Information The online version contains supplementary material available at https://doi.org/10.1186/s12943-021-01336-4. [Extracted from the article]