合并不同疾病的男性骨量异常患者骨代谢、骨密度及骨折情况研究.

Objective To investigate the bone complicated index, bone density and fracture in male patients with abnormal bone mass with different diseases. Methods A retrospective study was conducted on 928 male patients with abnormal bone mass who were admitted to the department of endocrinology of the first people's hospital of Shanghai from January 2006 to December 2017. According to different research purposes, the patients were divided into groups with or without diabetes, with or without chronic liver disease, with or without chronic kidney disease, with or without chronic stomach disease, with or without cardiovascular disease, and with or without bone mass loss and osteoporosis according to the study purpose. Observe the difference of various indicators in each group respectively. Results Univariate regression analysis suggested that the patients' age, weight,L1-4 BMD, femoral neck BMD, total hip BMD, myo-ctx, chronic gastric disease and osteoporosis were the influencing factors of fracture history, the differences were statistically significant (P<0.05), and fracture history was positively correlated with patients' age, myo-ctx, chronic gastric disease and osteoporosis.It was negatively correlated with body weight, L1-4 BMD, femoral neck BMD and total hip BMD. The multivariate regression analysis suggested that age, BALP, type 2 diabetes and osteoporosis were the risk factors for fractures, while the level of 25OHD was a protective factor for fractures. Conclusion Among the male patients with abnormal bone mass, it is necessary to focus on those older patients with higher levels of β-CTX and BALP, combined with chronic gastropathy and type 2 diabetes, and to carry out active anti-osteoporosis intervention and treatment to reduce the incidence of fractures in these patients. [ABSTRACT FROM AUTHOR]