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Candidemia in Children with Malignancies: Report from the InfectionWorking Group of the Hellenic Society of Pediatric Hematology-Oncology.
- Source :
-
Journal of Fungi . Dec2020, Vol. 6 Issue 4, p1-8. 8p. - Publication Year :
- 2020
-
Abstract
- Candidemia is an important cause of morbidity and mortality especially in immunocompromised and hospitalized patients. We retrospectively collected data of candidemia cases that occurred in the seven Hematology-Oncology Departments/Units of Greece and the Stem Cell Transplant Unit between 2015 and 2019. In total, 19 episodes of candidemia in 19 patients were recorded. The majority of the patients (78.9%) had at least one risk factor for candidemia. The most frequent risk factors associated with candidemia observed in our patients were prolonged duration of hospitalization (30 days, range 1-141), presence of a central venous catheter at diagnosis of candidemia (73.7%) and antibiotics use during the last two weeks (84.2%). Candida parapsilosis was the most common species isolated accounting for 42.1%, followed by C. albicans (26.3%) and C. famata (15.8%). Nearly all of the patients (84.2%) received antifungal monotherapy with liposomal amphotericin B or echinocandins. The central venous catheter was removed in 78.6% of patients and the median time between the first positive blood culture and catheter removal was 3 days (range 1-9). Mortality at 28 days was 26.3%. In conclusion, a predominance of non-albicans species was observed in our study in conformity with the global trend. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANDIDEMIA
*HEMATOLOGY
*HOSPITAL care
*ANTIBIOTICS
*ONCOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 2309608X
- Volume :
- 6
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Fungi
- Publication Type :
- Academic Journal
- Accession number :
- 149094882
- Full Text :
- https://doi.org/10.3390/jof6040276