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Real-time monitoring viscosity variation in carcinogenesis evolution models by a red-emitting rotor.

Authors :
Lu, Bingli
Yin, Junling
Liu, Cong
Lin, Weiying
Source :
Dyes & Pigments. Apr2021, Vol. 188, pN.PAG-N.PAG. 1p.
Publication Year :
2021

Abstract

Monitoring of the viscosity levels in cells and tissues is of great significance for the preliminary diagnosis related to abnormal viscosity. However, tracking of the viscosity level of tumors in different growth stages at the tissue level has not been reported. Therefore, a new viscosity-sensitive fluorescent probe (TA-I) with large Stokes shift and high viscosity dependence is in this work designed to visualize the viscosity level of tumors at different growth stages. And this probe exhibited a 20-fold fluorescence enhancement in viscous medium. With the aid of TA-I , a rapidly increasing fluorescent signal (16 times) was captured in the cells stimulated by exogenous stimuli, and the probe was also successfully applied to monitor viscosity changes in inflammatory mice. In addition, the viscosity levels in tumor tissues of mice at different growth stages (3 days, 6 days and 10 days) were also visualized in tissue level and revealed that the intratumoral viscosity level is highly dependent on tumor growth period. Importantly, the decreased viscosity of drugs-treated tumor tissue was obtained by the probe. It is worth noting that this is the first time to visualize the viscosity change rule of tumor at different growth stages at the tissue level. Image 1 • A new fluorescent sensor for potential tumor diagnosis. • Large stokes shift, high sensitivity, excellent photo-stability and desirable biocompatibility. • Visualizing at tissues level the viscosity changes of tumors in different growth stages. • Firstly tracking the viscosity changes from drugs-treated tumor mice at tissues level. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01437208
Volume :
188
Database :
Academic Search Index
Journal :
Dyes & Pigments
Publication Type :
Academic Journal
Accession number :
149126557
Full Text :
https://doi.org/10.1016/j.dyepig.2021.109170