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MYCN-amplified neuroblastoma cell-derived exosomal miR-17-5p promotes proliferation and migration of non-MYCN amplified cells.
- Source :
-
Molecular Medicine Reports . Apr2021, Vol. 23 Issue 4, pN.PAG-N.PAG. 1p. - Publication Year :
- 2021
-
Abstract
- Neuroblastoma (NB) is considered a highly prevalent extracranial solid tumor in young children, and the upregulation of N-myc proto-oncogene (MYCN) is closely associated with the late stages of NB and poor prognostic outcomes. The current study was designed to evaluate the effects of exosomal microRNA (miRNA/miR)-17-5p from MYCN-amplified NB cells on the proliferative and migratory potential of non-MYCN amplified NB cells. miR-17-5p was found to activate the PI3K/Akt signaling cascade by targeting PTEN, and the overexpression of miR-17-5p was found to promote cellular migration and proliferation in vitro. Further experimentation revealed that the elevated expression of miR-17-5p in SK-N-BE(2) cell-derived exosomes significantly promoted the proliferative and migratory capacities of SH-SY5Y cells by inhibiting PTEN. Collectively, these findings demonstrated that miR-17-5p derived from MYCN-amplified NB cell exosomes promoted the migration and proliferation of non-MYCN amplified cells, highlighting an exosome-associated malignant role for miR-17-5p. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUROBLASTOMA
*EXOSOMES
*TUMORS in children
*CELL proliferation
*MICRORNA
Subjects
Details
- Language :
- English
- ISSN :
- 17912997
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Molecular Medicine Reports
- Publication Type :
- Academic Journal
- Accession number :
- 149135348
- Full Text :
- https://doi.org/10.3892/mmr.2021.11884