PD-L1+ neutrophils contribute to injury-induced infection susceptibility.

Authors :: Thanabalasuriar, Ajitha
Chiang, Abby J.
Morehouse, Christopher
Camara, Margarita
Hawkins, Shonda
Keller, Ashley E.
Koksal, Adem C.
Caceres, Carolina S.
Berlin, Aaron A.
Holoweckyj, Nicholas
Takahashi, Virginia N.
Cheng, Lily
de los Reyes, Melissa
Pelletier, Mark
Patera, Andriani C.
Sellman, Bret
Hess, Sonja
Marelli, Marcello
Boo, Chelsea C.
Cohen, Taylor S.
Source :: Science Advances. 3/3/2021, Vol. 7 Issue 10, p1-14. 14p.
Publication Year :: 2021
Abstract: The article presents a study that explores the programmed death ligand 1 (PD-L1) neutrophils contribute to injury-induced infection susceptibility. It describes a rapid increase in neutrophil cell numbers in the lungs following induction of thermal injury. It provides evidence that injury promotes changes to neutrophils that are important for wound healing but contribute to infection susceptibility.