Back to Search
Start Over
Timing and dosage of and adherence to hormone replacement therapy and fracture risk in women with menopausal syndrome in Taiwan: A nested case-control study.
- Source :
-
Maturitas . Apr2021, Vol. 146, p1-8. 8p. - Publication Year :
- 2021
-
Abstract
- <bold>Objective: </bold>To investigate the association between hormone replacement therapy (HRT) and the risk of bone fracture in menopausal women in Taiwan.<bold>Study Design: </bold>The longitudinal, population-based, nested case-control study in Taiwan involved 5269 women aged > 45 years with fractures and 21,076 matched randomly selected controls without fractures. A conditional logistic regression model of analysis was employed.<bold>Main Outcome Measures: </bold>The association between the risk of bone fracture and various HRT-related parameters, including the timing, dosage, and adherence, was investigated.<bold>Results: </bold>Women with menopausal syndrome were protected from fractures when they received hormone drugs at high cumulative defined daily doses (DDDs) (Cumulative DDDsâ„360) (odds ratio [OR]: 0.90, 95 % confidence interval [CI]: 0.82-0.99) and when their adherence was high (over 0.5) (OR: 0.70, 95 % CI: 0.60-0.82). The risk of fracture also decreased with high cumulative DDDs and high adherence combined (OR: 0.71, 95 % CI: 058-0.86). Subgroup analyses suggested that estrogen-containing regimens showed a protective effect against fractures at high cumulative DDDs or when adherence was high. Similar results were also observed with progestogen-containing regimens. Past exposure to an estrogen-containing regimen showed a protective effect against fractures when adherence was high. Past exposure to a progestogen-containing regimen showed a protective effect against fractures at high cumulative DDDs and when adherence was high.<bold>Conclusions: </bold>The results indicate that past exposure to estrogen-containing or progestogen-containing regimens exerts protective effects against bone fracture. These effects increased with higher cumulative DDDs and with adherence in a dose-dependent manner. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03785122
- Volume :
- 146
- Database :
- Academic Search Index
- Journal :
- Maturitas
- Publication Type :
- Academic Journal
- Accession number :
- 149243761
- Full Text :
- https://doi.org/10.1016/j.maturitas.2020.12.010