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Debaryomyces is enriched in Crohn’s disease intestinal tissue and impairs healing in mice.

Authors :
Jain, Umang
Heul, Aaron M. Ver
Xiong, Shanshan
Gregory, Martin H.
Demers, Elora G.
Kern, Justin T.
Lai, Chin-Wen
Muegge, Brian D.
Barisas, Derek A. G.
Leal-Ekman, J. Steven
Deepak, Parakkal
Ciorba, Matthew A.
Liu, Ta-Chiang
Hogan, Deborah A.
Debbas, Philip
Braun, Jonathan
McGovern, Dermot P. B.
Underhill, David M.
Stappenbeck, Thaddeus S.
Source :
Science. 3/12/2021, Vol. 371 Issue 6534, p1154-1159. 6p. 4 Diagrams.
Publication Year :
2021

Abstract

Alterations of the mycobiota composition associated with Crohn’s disease (CD) are challenging to link to defining elements of pathophysiology, such as poor injury repair. Using culture-dependent and -independent methods, we discovered that Debaryomyces hansenii preferentially localized to and was abundant within incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD human subjects. D. hansenii cultures from injured mice and inflamed CD tissues impaired colonic healing when introduced into injured conventionally raised or gnotobiotic mice. We reisolated D. hansenii from injured areas of these mice, fulfilling Koch’s postulates. Mechanistically, D. hansenii impaired mucosal healing through the myeloid cell–specific type 1 interferon–CCL5 axis. Taken together, we have identified a fungus that inhabits inflamed CD tissue and can lead to dysregulated mucosal healing. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00368075
Volume :
371
Issue :
6534
Database :
Academic Search Index
Journal :
Science
Publication Type :
Academic Journal
Accession number :
149257666
Full Text :
https://doi.org/10.1126/science.abd0919