Vaginal Septa Caused Atresia with Hydrometrocolpos Syndrome in BALB/c Mice.

A total of 26 mice were observed with vaginal septa and 10 of them progressively developed into vaginal atresia. Among these vaginal atresia mice, 6 mice eventually suffered from uterus hydrometrocolpos syndrome (HMCPS) and polycystic ovary syndrome (PCOS) and the others were cured with surgical intervention once the vaginal orifices were found closed. Imaging and pathological observation showed that vaginal atresia led to cervix's lipoid secretion and uterine effusion. Moreover, Serum biochemical examination and ELISA test revealed significantly dramatic drop (about 50%) in blood triglycerides (P<0.01) and double increase in aromatase (P<0.01) in vaginal atresia mice. These findings give gained variable insight into further studies and provide vital guide for therapy on vaginal atresia. [ABSTRACT FROM AUTHOR]