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Conception and bicentric validation of the proSCANNED score, a simplified bedside prognostic score for Heart Failure patients.

Authors :
Duflos, Claire
Solecki, Kamila
Galinier, Michel
Itier, Romain
Roncalli, Jerome
Goger, Anne-Laure
Mandoraah, Bara
Kalmanovich, Eran
Huet, Fabien
Agullo, Audrey
Delseny, Delphine
Macia, Jean-Christophe
Leclercq, Florence
Mercier, Gregoire
Roubille, François
Source :
Scientific Reports. 3/17/2021, Vol. 11 Issue 1, p1-10. 10p.
Publication Year :
2021

Abstract

A simple and accurate prognostic tool for Heart Failure (HF) patients is critical to improve follow-up. Different risk scores are accurate but with limited clinical applicability. The current study aims to derive and validate a simple predictive tool for HF prognosis. French outpatients with stable HF of two university hospitals were included in the derivation (N = 134) or in the validation (N = 274) sample and followed up for a median of 23 months. Potential predictors were variables with known association with mortality and easily available. The proSCANNED risk score was derived using a parametric survival model on complete case data; it includes 8 binary variables and its values are 0–8. In the validation sample, the ability of the score to discriminate the 1-year vital status was moderate (AUC = 0.71, IC95% = [0.64–0.71]). However, the stratification of the score in three groups showed a good calibration for patients in the low- and medium-risk risk group. The proSCANNED score is an easy-to-use tool in clinical practice with a good discrimination, stability, and calibration sufficient to improve the medical care of patients. Other follow up studies are necessary to assess score applicability in larger populations, and its impact. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
Academic Search Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
149336386
Full Text :
https://doi.org/10.1038/s41598-021-85767-5