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Replication, pathogenicity, and transmission of SARS-CoV-2 in minks.
- Source :
-
National Science Review . Mar2021, Vol. 8 Issue 3, p1-8. 8p. - Publication Year :
- 2021
-
Abstract
- Minks are raised in many countries and have transmitted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to humans. However, the biologic properties of SARS-CoV-2 in minks are largely unknown. Here, we investigated and found that SARS-CoV-2 replicates efficiently in both the upper and lower respiratory tracts, and transmits efficiently in minks via respiratory droplets; pulmonary lesions caused by SARS-CoV-2 in minks are similar to those seen in humans with COVID-19. We further found that a spike protein-based subunit vaccine largely prevented SARS-CoV-2 replication and lung damage caused by SARS-CoV-2 infection in minks. Our study indicates that minks are a useful animal model for evaluating the efficacy of drugs or vaccines against COVID-19 and that vaccination is a potential strategy to prevent minks from transmitting SARS-CoV-2. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SARS-CoV-2
*COVID-19
*DRUG efficacy
Subjects
Details
- Language :
- English
- ISSN :
- 20955138
- Volume :
- 8
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- National Science Review
- Publication Type :
- Academic Journal
- Accession number :
- 149415002
- Full Text :
- https://doi.org/10.1093/nsr/nwaa291