黄韧带组织肥厚纤维化信号通路及分子水平的特征.

BACKGROUND: Ligamentum flavum hypertrophy is considered to be the main cause of lumbar spinal stenosis. In recent years, it has been reported that hypertrophy of the ligamentum flavum is related to growth factors, microRNAs and key signaling pathways. OBJECTIVE: To make a systematic review on the molecular level and signaling pathway of hypertrophic fibrosis of the ligamentum flavum. METHODS: Chinese and foreign databases, including CNKI, VIP, WanFang, PubMed, Biosos Preview, and Web of Science, were searched for relevant articles, and the basic experiments of hypertrophic fibrosis of the ligamentum flavum were collected by hand. The search terms included “lumbar spinal stenosis; hypertrophy of ligamentum flavum; ligamentum flavum hyperplasia; fibrosis of ligamentum flavum; cell factor; protein; signal path; microRNA” in Chinese and English, respectively. The retrieval time limit was set as June 30, 2020. The retrieved articles were screened in strict accordance with the inclusion criteria, and finally 15 relevant basic experimental articles were reviewed. RESULTS AND CONCLUSION: In the process of hypertrophic fibrosis, the ligamentum flavum can be affected by a variety of growth factors, miRNAs and multiple signaling pathways. Therefore, it is rational to speculate that the proliferation and fibrosis of the ligamentum flavum is a consequence of multi-dimensional coordination by multiple biological processes. However, the degree of fibrosis has not been determined yet, and further basic research is still needed in the future. [ABSTRACT FROM AUTHOR]